levoketoconazole will boost the degree or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

The novel wake-advertising and marketing agent modafinil has long been in use to the remedy of quite a few slumber Problems for your couple of years and is also now undergoing scientific trials for its use within the treatment method of stimulant dependancy, but its Main mechanism of motion remains elusive. Former laboratory scientific tests have revealed that modafinil has antioxidative and neuroprotective outcomes, which have not Earlier been recommended to generally be relevant to its wake-promoting effects. However, the latest investigation indicates that no cost radicals can be associated with sleep induction together with mobile injury, suggesting that a typical goal of motion may perhaps mediate modafinil’s capacity to oppose both of those outcomes.

modafinil will lower the level or effect of iobenguane I 131 by Other (see remark). Steer clear of or Use Alternate Drug. Depending on the system of action of iobenguane, prescription drugs that lower catecholamine uptake or that deplete catecholamine shops might interfere with iobenguane uptake into cells, and so, decrease iobenguane efficacy.

Medication which have quantity limitations related to each prescription. This restriction typically limitations the amount of the drug which will be covered.

cenobamate will improve the amount or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Carefully. Consider a dose reduction of CYP2C19 substrates, as clinically appropriate, when employed concomitantly with cenobamate.

These success propose that modafinil exerts a neuroprotective effect as a result of its capacity to attenuate or avert oxidative damage.

ketoconazole will improve the stage or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use click here Warning/Watch.

larotrectinib will raise the degree or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.

Allergic reactions for instance rash, angioedema, anaphylaxis, and Stevens–Johnson syndrome might hardly ever be brought on by an immunological response to modafinil or its metabolites.

Due to inconsistencies among the drug labels on DailyMed and also the capsule images provided by RxImage, we no longer Display screen the RxImage tablet visuals connected with drug labels.

rifapentine will lessen the level or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

efavirenz will reduce the level or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

eslicarbazepine acetate will improve the stage or influence of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of.

Watch Carefully (1)levoketoconazole will boost the degree or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.